Association between Metals Exposure with Renal Function and Biomarkers of Cardiovascular Effect in Shipyard Welding Workers

• Main Authors: WANG, WEN-JUAN, 王文涓
• Other Authors: LAI, CHING-HUANG
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/b4w6j5

碩士 === 國防醫學院 === 公共衛生學研究所 === 106 === Background: There are more than 3 million workers working on welding as the main work item. Welding fume, a complex mixture which produced by high temperature, the metal compositions are more likely to affect the health of shipyard employees. The metals which in the fume may lead to the incidence of chronic diseases. Chronic kidney disease is one of the important disease that has high prevalence and high incidence, and it has a lot of common risk factors with cardiovascular disease. Objective: The objective of this longitudinal study was to explore the relationship between urinary metals, urinary 1-hydroxypyrene and estimated Glomerular filtration rate (eGFR), Framingham coronary heart disease risk score (FCRS). Material and methods: The study subjects in this longitudinal study were the employees of a shipyard in northern Taiwan, data were collected and follow-up in the duration between September and October of each year from 2014 to 2016. Personal air sampling, questionnaires and health check were conducted in the corresponding time and calendar year. We took shipyard employees’ urinary metal and urinary 1-OHP as biomarkers of exposure. Estimated Glomerular filtration rate (eGFR) with the formula of MDRD, and Framingham coronary heart disease risk score (FCRS) were calculated as the indicator of kidney function and cardiovascular effect. Results: Our study showed that the level of fine particles (PM2.5) of the shipyard workers were significantly higher than office workers (p=0.007). Regarding to the biomarker of internal dose, urinary 1-OHP of the shipyard workers were significantly higher than office workers (p<0.001). As the levels of urinary 1-OHP, urinary chromium, urinary cobalt, urinary nickel, urinary zinc, urinary cadmium, urinary iron and urinary vanadium increased, triglyceride was significant increased. In the linear regression, we found that T-CHO/HDL increased as urinary zinc, iron and vanadium increased (log μg/L). While the more urinary manganese, zinc and iron (log μg/L), the more LDL/HDL. After adjusted for urinary creatinine, eGFR significantly decreased as urinary manganese increased (p=0.021). In Generalized Estimating Equations (GEE) analyses, it showed that FCRS scores increased as the levels of urinary cobalt, chromium, iron, vanadium increased after adjusting for age, smoking status, time and urinary creatinine. And we also found that eGFR significantly decreased as urinary chromium increased. Conclusion: Our study showed that the concentration of the urinary metal was significantly associated with biomarkers of cardiovascular effect and kidney function in the shipyard workers. It implicates that exposure to metal increases the risk of cardiovascular effects and decrease renal function.