The interaction between apnea-hypopnea index and sleep quality on the risk of metabolic syndrome

• Main Authors: PAO, PEI-WEN, 包佩雯
• Other Authors: CHOU, YU-CHING
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/cbfan2

碩士 === 國防醫學院 === 公共衛生學研究所 === 106 === Background:Sleep apnea is one of the reasons affecting sleep quality and accompany with metabolic syndrome (MS) frequently. In this study, we take sleep apnea index as an observational index of sleep apnea to investigate the relationship between metabolic syndrome and sleep quality. Aims:To investigate the interaction of sleep apnea index, sleep quality and MS and each subject’s independence. Methods:This study adopts a cross-sectional design. The case was collected from the sleep database of a sleep center in a medical center in central Taiwan. A total of 659 valid samples were collected from the sleep examinations conducted between January 2007 and December 2013 in the Sleep Center. Pittsburgh Sleep Quality Index, AHI Index, basic structural questionnaires for sleep examinations, personal multiple physical sleep and basic outpatient data were collected and been analyzed. Results: As AHI normal was reference group, AHI mild (OR=1.74, 95% CI:1.15-2.65), AHI moderate (OR=2.38, 95% CI:1.44-3.94), and AHI severe (OR=3.17, 95% CI:1.95-5.16) and MS risk were statistical significantly. AHI severity was independent effect of MS. Although subjective sleep quality (PSQI) and MS was not statistical significantly (OR= 0.99, 95% CI: 0.68-1.47),objective indicators of sleep were related to the MS. The odds ratios of AHI abnormalities & poor sleep quality (OR= 2.18, 95% CI:1.16-4.12) and AHI abnormalities & good sleep quality (OR= 2.11, 95% CI :1.03-4.30) were reached a significant level (vs.AHI normal & good sleep quality). When the AHI abnormalities and sleep quality were good, and the AHI abnormalities and sleep quality were poor in the individual cases, the risk of metabolic syndrome was higher than that of normal AHI and good sleep quality, so they had interactions. Conclusion:AHI severity and sleep quality showed significant interaction. Further study about this interaction and relationship with sleep apnea and metabolic syndrome comorbidity was needed to translate to primary prophylaxis through elevate awareness and behavior modification.