Studies on the chemical constituents and their bioactivity from the Formosan coral Briareum violaceum

• Main Authors: Jing-Hao Xu, 許景皓
• Other Authors: Ping-Jyun Sung
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/2z6xpb

碩士 === 國立東華大學 === 海洋生物研究所 === 106 === Studies on the chemical constiuents of the cultured soft coral Briareum violaceum had isolated twelve briarane-type diterpenoids, including seven new compounds named briaviolides K¬–Q (1–7), along with five know compounds, 2-acetoxy-2-(debutyryloxy)stecholide E (8), stecholide C acetate (9), excavatoid E (10), 2-acetoxy-2-(debutyryloxy)stecholide E acetate (11) and excavatolide Z (12). Structures of compounds 1–12 were determined by spectroscopic methods, and comparison of the spectroscopic data with other related metadolites. In addition, those compounds are tested for anti-inflammatory activity. As a result, compound 5 was found to display inhibitory effect on the accumulation of the pro-inflammatory iNOS protein in the LPS-stimulated RAW264.7 macrophage cell at a concentration of 10 M (reduced to 10.53±1.38 %).