Response-adaptive randomization for multi-armed survival trials
碩士 === 國立成功大學 === 統計學系 === 106 === In clinical trials, response-adaptive randomization becomes popular recently. Because it can change the allocation probabilities sequentially, with the main goal of assigning more patients to the better treatment. However, most relevant references focus on two-arme...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2018
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| Online Access: | http://ndltd.ncl.edu.tw/handle/j3g5d8 |
| Summary: | 碩士 === 國立成功大學 === 統計學系 === 106 === In clinical trials, response-adaptive randomization becomes popular recently. Because it can change the allocation probabilities sequentially, with the main goal of assigning more patients to the better treatment. However, most relevant references focus on two-armed clinical trials especially that response outcome is survival. In this paper, we derived two optimal allocation proportions for multi-armed survival trials. And the doubly adaptive biased coin design is applied to develop a randomization procedure. In order to compare the efficacy of treatments, we use multiple Wald test to control the Type I error rate not higher than significant level α. Through simulation study, we verified our method can allocate patients to most efficacious treatment than the popular balance designs. We also illustrate our allocation procedure by redesigning a four-armed prostate cancer trial and make comparisons with balance designs.
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