1. CuI/Oxalic Diamide-Catalyzed Cross－Coupling of Thiols with Aryl Chlorides2. Application of C－S Bond Formation on Vortioxetine Synthesis

• Main Authors: Yi-Ling Chen, 陳以鈴
• Other Authors: Chin-Fa Lee
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/99b5d6

碩士 === 國立中興大學 === 化學系所 === 106 === In the first part of this thesis, we report a general copper-catalyzed cross-coupling of thiols with aryl chlorides by using N,N''-dialkyl oxalic diamide (L5) as the ligand. Both aryl- and alkyl thiols can be coupled with unactivated aryl chlorides to give the desired products in good yields for the first time. Furthermore, this system features broad substrate scope and good tolerance of functional groups. Importantly, the oxalic diamides are stable and can be prepared easily from commercially available cheap starting materials. The second part of this thesis, application of this copper-catalyzed cross-coupling of 2,4-dimethylyhiophenol with 1,2-diiobenzene by using N,N''-dialkyl oxalic diamide (L5) as the ligand has been described for the synthesis of antidepressant Vortioxetine.