To Explore Danheiser [3+2]-(trimethylsilyl)cyclopentene Annulation for (+)-Fawcettimine Synthesis
碩士 === 國立中興大學 === 化學系所 === 106 === This seminar is to explore Danheiser [3+2]-(trimethylsilyl)cyclopentene annulation which is available for combining functionalized allene with cyclohexenone together to construct cis-hydrindane with stereoselectivity. Therefore, using cheap 1-Bromo-3-chloropropane...
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| Format: | Others |
| Language: | zh-TW |
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2018
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| Online Access: | http://ndltd.ncl.edu.tw/handle/5cn6g4 |
| Summary: | 碩士 === 國立中興大學 === 化學系所 === 106 === This seminar is to explore Danheiser [3+2]-(trimethylsilyl)cyclopentene annulation which is available for combining functionalized allene with cyclohexenone together to construct cis-hydrindane with stereoselectivity. Therefore, using cheap 1-Bromo-3-chloropropane as a starting material that can be readily catalyzed by phase transfer catalysts (PTCs). Then, exploring synthetic methods for allenes by protecting different kinds of functional groups on them. Furthermore, trying to discuss the effects that allenes combined together with 5-methyl cyclohexan-2-en-1-one which is developed by (R)-(+)-pulegone.
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