An Investigation of the Risk Factors for Prediction Pneumonia among Schizophrenia Inpatients

• Main Authors: Liang-Chih Cheng, 鄭良志
• Other Authors: Kuang-Ming Kuo
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/9kx6u9

碩士 === 義守大學 === 醫務管理學系 === 106 === Backgroubd and purpose: Schizophrenia regards as severe mental disorder diseases. Ever increaing patients are treated with medications mainly, though 2nd generation antipsychotic Clozapine has less extrapyramidal symptoms still left serious adverse effect, including pneumonia. This thesis focus on study of Clozapine Induced Pneumonia and other risk factors. Materials and Methods: This thesis investigate on how Schizophrenia patients after taking Clozapine and other factors might lead to pneumonia. The research main focus includes variable factors of population, medications, blood tests and physical assesments. Use study of Chart review method was used to collect inpatients from southern Taiwan mental hospital. Results and Conclusions: 217 hospitalized patients data retracted from central of disease control (CDC) archives during period of 1-9-2013 till 2-28- 2018. Logistic Regression analysis shown 80 Schizophrenia patient taken Clozapine developed penumonia (β = 2.71，p ＜ .05), 15 times more than those without; male (β = 2.02，p ＜ .05) and blood sugar (β = -0.13，p ＜ .05) also positive related which considerd as risk factors, furthermore, male pneumonia complications is 7.55 times more than female; one degree of blood sugar increment, pneumonia complications increase 1.33 times. Besides, Chi-square test results show that drug interactions are associated with pneumonia (χ2 = 5.20，p ＜ .05); Two sample t test indicated that Clozapine cause low WBC count (t = -3.70，p ＜ .001) , low neutrophil (t = -5.40，p ＜ .001). This research concluded that special attention should be given to male inpatients with schizophrenia, taking Clozapine drugs, generating drug interactions, and closely monitoring blood glucose, white blood cell count, and neutrophil numbers to prevent the development of pneumonia.