| Summary: | 碩士 === 義守大學 === 生物醫學工程學系 === 106 === Farnesol is, a natural 15-carbon organic compound, has been found to increase the synthesis of collagen of fibroblasts. It is often used as an ingredient in cosmetic products, less in the applications of wound healing from sunburn and moderate/heavy burns. In the current study, the capability of farensol in collagen synthesis and farensol-containing gels were designed to evaluate the repairing effects on injured skin. The obtained results the farensol is non-toxic under the concentration of 0.3 mM and able to stimulate fibroblasts to secret collagen. Gel containing hydroxypropyl methylcellulose (HPMC), hyaluronan (HA), xanthan gum (XG) and farnesol revealed that could occlude the UVB light and retain the cell cycle of fibroblasts. The sunburn animal study results also indicated that the prepared gels could decrease the inflammatory effect after sunburn and increase the collagen synthesis. A plural gel containing farensol liposomes (using as a slow release agent) was also prepared to evaluate the healing effects of farensol liposomes in burn-injured rats. The results indicated that the liposomal farensol has non-toxic characteristics, the farensol liposomes exhibited good spherical shape and with average size of 100 ± 30 nm in diameter. The 31% of encapsulated farensol released after 48 hours incubation. Importantly, the gel containing liposomal farensol decreased the IL-6 factor expression and stimulated the fibroblasts synthase the collagen after burn injury in SD rats.
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