Effects of intervention of total parenteral nutrition on body weight and nutritional status of patients with hematopoietic stem cell transplantation

• Main Authors: Chung-Yan Lee, 李忠諺
• Other Authors: Wei-Yi Zheng
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/jqdg44

碩士 === 義守大學 === 化學工程學系暨生物技術與化學工程研究所 === 106 === Purpose:Hematopoietic stem cell transplantation (HSCT) is a general term that includes bone marrow transplantation (BMT), peripheral blood stem cell transplantation (PBSCT), and cord blood transplantation (CBT). Studies have found that weight loss in HSCT patients has been attributed with significant morbidity and mortality. Intravenous nutritional support can improve the patient''s nutritional status, but the use of routine total parenteral nutrition (TPN) remains controversial.Methods:A total of 102 patients who underwent bone marrow transplantation at Kaohsiung Veterans General Hospital during 2013-2017 were analyzed. Age, gender, infection, diagnosis, position measurement data, abdominal circumference, length of hospital stay, number of days in the transplant room, number of deaths within 100 days, data on TPN use, proportion of stem cell types.Result:After the bone marrow transplantation process, the average weight of the TPN was increased by 1.1 kg, and the weight without the TPN was reduced by 1.6 kg. There was a significant difference between the two groups (p=0.01).The probability of infection was not increased by the difference in the use of TPN and the time of intervention or the source of stem cells was autologous or allogeneic; the change in albumin was statistically different (p=0.01) in the presence or absence of TPN. However, there may still be research limitations that lead to differences in results.Conclusion: The intervention of TPN does not increase the risk of infection and contributes to the maintenance of weight during the transplant, but has no effect on the length of hospital stay and the number of days in the transplant room.