| Summary: | 碩士 === 中原大學 === 機械工程研究所 === 106 === This thesis presents a paper-based chip with nickel-cobalt nanowires for non-enzymatic glucose electrochemical detection. Nickel-cobalt nanowires were prepared by electrodeposition using anodized aluminum template. The as-prepared nanowires were characterized by field-emission scanning electron microscope. In addition, the condition to modify the surface of screen printed carbon electrodes (SPCE) using graphene as a nano-framework for nanowires, the effect of different diameters of nanowires, and the dose of required nanowires were discussed to study the electrocatalytic effect for glucose by cyclic voltammetry. Thus, the optimized paper-based chip was obtained. Based on the experimental results, the paper-based chip with 12 μl of 200 μm Ni-Co nanowire dropcasted on graphene of SPCE had the best catalytic effect. This chip was able to detect glucose within a wide range of concentrations from 4 μM to 8 mM, which covers the range of physiological levels. The detection limit was 4 μM. Moreover, the chip had good anti-interference ability, and was not inferenced by chloride ions. Therefore, the the modified paper-based chip had a good detection ability in non-enzymatic glucose detection.
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