Fine Particulate Matter Cause Rodent Embryonic and Developmental Toxicity

• Main Authors: Jia-Yu Yu, 余佳語
• Other Authors: Ming-Wei Chao
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/wdmmce

碩士 === 中原大學 === 生物科技研究所 === 106 === Air Pollution increases as progress of technology, and became a popular issue in recent years. The fine particulate matter is one of air pollution, which is carbon as the core and adsorption of organic matter, heavy metals and other substances, and particle size is less than 2.5 μm. Fine particulate matter can into our body by respiration, and it reach the bronchi, than translocate to blood vessel and then affect whole body through the blood circulation system. When pregnant women inhaled air, the offspring will also be affected. It has been report that exposed to fine particulate matter during pregnancy, new born may have congenital heart disease, miscarriage, premature birth, low birth weight, and central nervous system may also be affected. In order to know the effect of fine particulate matter on the development of the offspring, this study began from the preimplantation stage. To know the embryonic and developmental toxicity cause by fine particulate matters. We use blastocysts co-culture with fine particulate matters and intratracheal instillation in mice and rats to assess embryonic development and offspring development. Results show that fine particulate matters decreased the cell number of mouse blastocysts, increased apoptotic cell in blastocysts, and cause low implantation rate. Further, offspring that maternal fine particulate matter exposure, has learning and memory ability decreased, and injury neuron morphology.