Study of Zwitterionized Polypropylene Fibrous Membranes Prepared by Interpenetrating Polymer Networks and Their Biocompatibilities

• Main Authors: Po-Ju Chen, 陳柏如
• Other Authors: Yung Chang
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/pxb865

碩士 === 中原大學 === 化學工程研究所 === 106 === This study describes a facile approach for the surface modification of polypropylene non-woven membranes by poly(glycidyl methacrylate-co-sulfobetaine methacrylate) (poly(GMA-co-SBMA)) which involves the use of interpenetration polymer network to allow the membrane surface to become hydrophilic. The surface modification involved the physical adsorption of poly(GMA-co-SBMA) with the help of a crosslinker, ethylenediamine (EDA), on the non-woven membrane surface for the increased biocompatibility of the material. Chemical characterization and morphological changes of the poly(GMA-co-SBMA) modified non-woven membrane sample surfaces were characterized in detail by Fourier transform infrared (FTIR) spectroscopy, Scanning electron micrograph (SEM), and water contact angle measurements. Biofouling tests were also conducted with the attachment of blood、protein and bacterial. Results reveal that the addition of EDA in the coating solution of poly(GMA-co-SBMA) significantly increases the hydrophilicity and grafting densities of the non-woven PP membranes which indicates that EDA is a good crosslinker and promotes the formation of an interpenetrating polymer network on the PP membrane. For the biofouling tests, the results also show decreased attachment for Fibrinogen protein, Escherichia coli and blood cells (erythrocytes, leukocytes, thrombocytes, whole blood) which indicates an increased biocompatibility for the modified PP membranes.The anti-fouling test results show that this modification method has a good effect, so try to tests blood filtration and wound dressings. The results of blood filtration show that hydrophilic PP nonwoven can pass blood smoothly without pressure and block white blood cells and platelet ; and hydrophilic PP nonwoven has a high hydration can provide a moist environment for wounds and allow for faster recovery. However, PP membrane materials are not only used in biomedical materials, but also used in water filters. We tried to use oil-water filtration and the results showed that the hydrophilic PP nonwoven had a good separation effect.