The 3D-printed strontium-costained calcium silicate scaffold for bone tissue engineering

• Main Authors: Ming-Jie Liu, 劉孟杰
• Other Authors: 高嘉澤
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/r8x7su

碩士 === 中山醫學大學 === 口腔科學研究所 === 106 === Strontium (Sr) is described as having a beneficial effect on bone strength and structure. However, oral administration of strontium ranelate can cause negative systemic effects, leading to limited clinical use. In the past, laboratory-developed calcium Silicate (CS) ceramics have proven that this material not only accelerates the growth of many kinds of cells but also promotes hard tissue differentiation of cells. Therefore, this study will use Sr to replace Ca in CS, and a new ceramic powder has been obtained. In the present study, three calcium tellurite containing ceramic powders (Sr0, Sr5, Sr10) and polycaprolactone (PCL) were used as 3D printed materials. After the ceramic powder and the PCL were uniformly heated and mixed, a porous scaffold was prepared through a 3D printer to perform mechanical properties, degradation properties, and cell-related tests. From the results, it can be seen that increasing the Sr content in the ceramic content will increase the mechanical strength of the stent, and after soaking in the bionic solution for seven days, it will also produce apatite precipitate on the surface of the stent. In cell observations, the content of Sr in the scaffold did not significantly increase cell growth, but in the analysis of alkaline phosphatase and calcium deposition, it was found that the Sr10 group was superior to other scaffolds. From the above results, it can be seen that the ceramic stent has great potential for bone tissue engineering applications in the future.