Regulatory effect of rutin drink on blood pressure

• Main Authors: Po-Jung Huang, 黃柏榮
• Other Authors: 王進崑
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/3n9bh6

碩士 === 中山醫學大學 === 營養學系碩士班 === 106 === Hypertension is one of the major risk factors for cardiovascular disease. Controlling blood pressure within the normal range can help to reduce the risk. Previous studies have found that rutin can inhibit angiotensin converting enzyme activity and reduce aldosterone to lower blood pressure in vitro and in vivo. The purpose of this study was to investigate the regulatory effect of rutin drink on blood pressure. In a randomized controlled trial, the experiment group received 2 cans of test drinks (60 mg rutin) daily for 12 consecutive weeks. The results showed that systolic blood pressure (β = -0.503, p < 0.001) and diastolic blood pressure (β = -0.458, p < 0.001) were significantly lowered in the experiment group. There was no significant change in angiotensin I and angiotensin II concentration in both groups. The reduced level of angiotensin converting enzyme (β = -1.277, p < 0.001) and aldosterone (β = -2.943, p = 0.042) concentration were found in the experiment group. In addition, angiotensin converting enzyme also showed positive correlations with systolic blood pressure (R = 0.601, p = 0.002) and diastolic blood pressure (R = 0.423, p = 0.039). Therefore, we conclude that the daily supplement of 2 cans of rutin drinks can help to downregulate blood pressure by lowering the concentration of angiotensin converting enzyme and aldosterone.