| Summary: | 碩士 === 中山醫學大學 === 健康餐飲暨產業管理學系碩士班 === 106 === Obese population worldwide has increased sharply in recent decades leading obesity to become a major global health issue. Obesity increases the risk of metabolic syndrome, and maintaining ideal body weight has a protective effect on many diseases. The purpose of this study is to investigate the effects of Astragalus membranaceus root and Panax pseudoginseng root extracts (APE) on a group of obese subjects (27BMI35). The study is a double blind randomized crossover human trial lasting twenty-eight weeks with two twelve-week phases and a four-week washout period in between the two phases. Subjects took either five APE or Placebo capsules every day during the two twelve-week phases (two capsules before breakfast and three capsules before dinner). Anthropometric measurements and biochemical indicators were measured during the study. A total of twenty one subjects (nine males and twelve females) completed the study. The study showed that subjects who took APE capsules lost 0.34 kg in body weight and lowered their BMI by 0.14 kg/m2 and body fat by 0.12%. Subjects who took the Placebo capsules increased their body weight by 0.45 kg, BMI by 0.16 kg/m2, and body fat by 0.12%. Compared with the Placebo group, BMI was significantly lower (p<0.05) by 0.3 kg/m2 in the APE group. In addition, subjects who took APE have trend of insulin resistance index decrease and adiponectin level increase. Furthermore, after 12 weeks, the antioxidative activity of the APE group showed thiobarbituric acid-reactive substances (TBARS) was decreased trend, glutathione reductase (GSH Rd) and superoxide dismutase (SOD) were increased trend. The total antioxidant capacity (TEAC), glutathione (GSH), and glutathione peroxidase (GSH Px) were siginificantly increased, but no different in the Placebo group. The biochemical levels and physiological functions of the subjects both in the APE and the Placebo groups were within the normal ranges and had no side effects. Based on the results, the study suggests that APE may be a part of an effective weight management product. APE also could to improve the antioxidative capacity.
|
|---|
