| Summary: | 碩士 === 中華科技大學 === 健康科技研究所在職專班 === 106 === In this study, polyacrylonitrile (PAN) membrane was treated with oxygen plasma, followed by graft-polymerization of N-vinylformamide (NVF), and hydrolysis to introduce an amino-group bearing surface. Subsequently, dextran sulfate (DS) (as an anti-adhesive agent) and chitosan (CS) (as an antibacterial agent) were alternatively deposited onto the aminolyzed PAN membrane in a layer-by-layer assembly manner, thereby constructing anti-adhesive and antibacterial polyelectrolyte complex (PEC) multilayer membranes. The progressive buildup of the multilayer membrane was verified by dye staining and XPS. These multilayer membranes were characterized with contact angle and scanning electron microscope (SEM). The in vitro evaluation of hemocompatibility was performed by measuring the adsorption of human serum albumin (HSA) and platelet adhesion. The results from SEM show that the surface roughness changed little with the deposition of PEC layers. The hydrophilicity was improved with the increase of the number of PEC layers. Thus this demonstrated an easy process to prepare an anti-adhesive, cytocompatible surface, and will be useful for surface modification of cardiovascular devices.
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