The nucleation kinetics of isonicotinamide based on induction time measurements in various solvents

• Main Authors: Tai Jyun Chen, 陳泰均
• Other Authors: L. D. Shiau
• Format: Others
• Language: zh-TW
• Published: 2018
• Online Access: http://ndltd.ncl.edu.tw/handle/xd8cbd

碩士 === 長庚大學 === 化工與材料工程學系 === 106 === A new model based on classical nucleation theory was developed in this work to elucidate the influence of solvent on the interfacial energy and pre-exponential nucleation factor of isonicotinamide at 30 ℃ using the induction time data. The results indicate that intrinsic nucleation rate constant increases linearly with increasing square root of interfacial energy in various solvents for this system. The obtained interfacial energy in this work showed a trend: methanol> acetone> acetonitrile> ethyl acetate. Scanning electron microscope was used to study the effects of different solvents on the size of isonicotinamide crystals. Scanning electron microscope showed that all crystals are form II. It was found that, as the interfacial energy increases among various solvents, the size of crystals gets larger.