| Summary: | 碩士 === 國立陽明大學 === 物理治療暨輔助科技學系 === 105 === Background and Objective: Frailty is now a geriatric syndrome and definable clinical syndrome with a simple screening test. Physical frailty is defined that common clinical features are slow walk speed and low muscle strength. Within the factors, inflammatory mediator-interleukin-6(IL-6) is an indicator to predict the decline of the body function and system. Previous studies have proved that exercise can stimulate the immune system and reduce complications. But there is not yet proved the most appropriate types of exercise on improve the inflammation status for seniors-housing physical frailty aged. This study developed a new type of multi-component exercise to improve IL-6 and muscle performance in addition to the reversion of physical frailty.
Materials and Methods: This was a prospective and nonrandomized control trial; a mass physical frailty screening using the modified Fried frailty criteria was conducted in senior houses. Subjects(Aged≧75) were assessed to multi-component exercise group(MCE) or usual care group(UC). MCE group received a 50-minute training three times a week for 12 weeks. Measure outcomes include IL-6 level, muscle performance and physical function.
Results: Forty-six subjects participated in this study and they were allocated into multi-component exercise group(N=23, 81.35±5.70 years old) and usual care group(N=23, 84.87±5.66 years old). After 12 weeks intervention, MCE demonstrated significant improvements on muscle performance including the peak power and peak torque/body mass of knee flexors in 180°(p<0.05), average power of knee extensors in 180°(p<0.05). Meanwhile, physical functions including 6 meter walking time(p<0.05), lower limb(p<0.001) and upper limb(p<0.001) muscle endurance, as well as cardiorespiratory endurance(p<0.01) had significantly improved. There were significant between-group differences in changes based on the group*time interaction effects. This study found the change of IL-6 had correlated to IGF-1(p<0.05), weight (p<0.05), peak torque of knee muscles in 60°(p<0.05)and average power of knee extensors in 60°(p<0.05). Regarding to reversion, the multi-component exercise ameliorated rating of physical frailty for senior-housing aged.
Conclusions and Recommendations: Multi-component exercise showed significant improvements on isokinetic muscular performance as well as functional fitness and maintained muscle mass. Appropriate exercise could reverse physical frailty and decrease amount of IL-6. While IL-6 decreased, the body function declined. Future investigations with larger sample size, the similar senior-housing environment and long-term follow-up to better evaluate the exercise effects are warranted.
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