| Summary: | 博士 === 國立陽明大學 === 生醫光電研究所 === 105 === Optical coherence tomography (OCT) is a popular optical imaging technology for more than a decade. OCT has high resolution, high sensitivity, and non-radiation. Therefore, this technology is very suitable for medical and biological research. In the time-domain OCT system (TDOCT), the system obtains depth information (A-Scan) when reference arm changes the length, which limits its imaging speed. In recent years, further developments in the OCT include the transformation of the technology from the TDOCT to the “Fourier-domain” OCT (FDOCT), including the swept source OCT (SSOCT) and frequency domain OCT (SDOCT). FDOCT allows imaging at higher rates compared to TDOCT. The SSOCT systems that combine with optical probe technology have been used in clinical medicine. The optical probe can insert into the different luminal tissues, so can observe and detect tissue changes. FDOCT technology combined with the optical catheter has been used in cardiovascular, dental and gastrointestinal. These applications have demonstrated that optical catheter of OCT has great potential in clinical medicine.
In this paper, we developed two kinds of fiber probes needed by the clinician. These probes were used for dental detection and anesthesia operation respectively. In the dental detection, using the numerical image analysis to distinguish the dental calculus successfully, dental demineralization and enamel pearls and receiver operating characteristic (ROC) curve proved the best sensitivity reach to area under the curve of ROC = 0.95 or more. In the anesthesia surgery, we successfully identified the epidural space location when needle inserts through the different tissues and find the anesthesia path. After that, we developed the automatic identification system for object distinguishing different tissue. Another application is using OCT fiber probe technology to locate the dura puncture hole; this is because when patients with dural rupture, cerebrospinal fluid outflows the epidural space, leads to brain pressure instability and results in a strong headache symptom. Therefore, we simulated the dural rupture using a piglet model and constructed a 3D image to locate the hole. The fiber probe of the OCT system is maybe critical in the treatment of Spontaneous intracranial hypotension (SIH) syndrome. Finally, we tried to integrate this mini-probe into an endoscopic esophageal imaging. The preliminary animal experiment shows that different layers in normal esophageal can be distinguished by using OCT images.
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