The analysis of diode laser application in facilitated blood coagulation

• Main Authors: Chao-Fu Chang, 張朝富
• Other Authors: Pei-Wen Peng
• Format: Others
• Language: en_US
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/3r68st

碩士 === 臺北醫學大學 === 生醫材料暨組織工程研究所 === 105 === After trauma or injuries, the wounded sites usually result to bleed. The blood will then undergo a physiological process called coagulation to achieve hemostasis in order to prevent excessive blood loss and to make the wound ready for further healing. However, the time required by the blood to start coagulating is determined by the individual’s phenotype through its coagulation cascade.1. There are several known diagnostic diseases or disorders which are related to the impairment of the coagulation cascade such as hemophilia, Von Willebrand disease, and deficiency of vitamin K… etc. In addition, drug application can also be a result of prolonged blood coagulation. This study; however, introduces a clinical method of directly and externally making a pool of blood instantly coagulate by the treatment of Diode laser. For example: to stop bleeding in a dental extraction sockets. LASERS （Light Amplification by Stimulated Emission of Radiation）emit a precise beam of monochromatic, coherent, and collimated light energy. The diode laser is a near-infrared continuous wave laser whose wavelength varies from 655nm to 980nm. The wavelength determines the absorption characteristic in biologic tissues.2 When the laser beam is applied to the tissue, the light energy is transformed into heat and causes a photo-thermal event resulting a temperature rise in the tissue. Different observed effects take place by different tissue temperature achieved. Coagulation begins at over 50°C, with protein denaturation at 60°C. Vaporization of water occurs at over 100°C, with carbonization of tissue at 200°C3,4. A typical laser surgery is achieved by the process of ablation, meaning tissue removal by converting it to a gaseous state or plume. Lasers have also been utilized to induce vascular occlusion and photocoagulation.