Chemotherapy-induced Stromal-epithelial Signaling and its Oncogenic Role in Desmoplastic Cancer

• Main Authors: Tze-Sian Chan, 張智翔
• Other Authors: Gi-Shih Lien
• Format: Others
• Language: en_US
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/j865d3

博士 === 臺北醫學大學 === 臨床醫學研究所 === 105 === Whilst traditional chemotherapy kills a fraction of tumor cells, it also activates the stroma and can promote the growth and survival of residual cancer cells to foster tumor recurrence and metastasis. Accordingly, overcoming the host response induced by chemotherapy could substantially improve therapeutic outcome and patient survival. Resistance to treatment and metastasis have been attributed to expansion of stem-like tumor-initiating cells (TICs). Molecular analysis of the tumor stroma in neoadjuvant-chemotherapy-treated human desmoplastic cancers and orthotopic tumor xenografts revealed that traditional maximal-tolerated-dose chemotherapy, regardless of the agents used, induces persistent STAT-1 and NF-κB activity in carcinoma-associated fibroblasts. This induction results in the expression and secretion of ELR-motif-positive (ELR+) chemokines, which signal through CXCR-2 on carcinoma cells to trigger their phenotypic conversion into TICs and promote their invasive behaviors, leading to paradoxical tumor aggression following therapy. By contrast, the same overall dose administered as a low-dose metronomic chemotherapy regimen largely prevented therapy-induced stromal ELR+-chemokine paracrine signaling, thus enhancing treatment response and extending survival of mice carrying desmoplastic cancers. These studies illustrate the importance of stroma in cancer therapy and how its impact on treatment resistance could be tempered by altering the dosing schedule of systemic chemotherapy.