The Studies of Neurobehavioral Changes after Repetitive Traumatic Brain Injury in Rats

• Main Authors: Kuo-Feng Hung, 洪國峯
• Other Authors: Wei-Chung Yang
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/x583nt

碩士 === 臺北醫學大學 === 臨床藥物基因體學暨蛋白質體學碩士學位學程 === 105 === Traumatic brain injury all over the world is an important public health issue, especially mild traumatic brain injury (mTBI). It is up to 80% in neurotrauma, especially repetitive mild traumatic brain injury (rmTBI) and another problem is chronic traumatic encephalopathy (CTE). Researchers pointed out that hyperphosphorylation of the tau protein, spreading astrocyte and microglial cell hyperplasia and chronic neuron degeneration etc. in some rmTBI patients the brain, that might reduce the lifespan and increase the neuron degenerative disease rate; however, diagnosis is still lacking and current treatment is also not very effective. In this studies, we used nine-week-old male Sprague-Dawley (SD) rats, which were randomly divided into two groups, as the control group (only Gas anesthesia treated) and the treatment group (rmTBI) by weight drop impact. Six tests were carried out for behavioral and cognitive tests to assess the degree of injury associated with the degradation of the behavioral and cognitive functions. In results, the gradations in impact pressure produced progressive degrees of injury severity in the balance function, neurological score as well as cognitive function. The test model of a rmTBI animal, which mimics the repetitive TBI patient’s injured conditions, may allow to follow the long-term observations and to develop an effective diagnosis, prevention, and treatment of behavioral and cognitive dysfunction.