The Application of Biological Measurement And Implementation of High Pulse Stimulation Circuit

• Main Authors: Chen Hsiao-Yi, 陳孝昱
• Other Authors: Chiu Hung-Wei
• Format: Others
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/tx63x4

碩士 === 國立臺北科技大學 === 電子工程系研究所 === 105 === Our research builds impedance measure model for biological, to simulate immediate measurement for human or animal cells where is under pulse signal. Most of the impedance measurements are static or under small signal, our simulation state is when high frequency pulse on cells, we can open the extracellular membrane and measure intracellular impedance value, with the impedance analyzer. In the measurement we add components to avoid current entering to the device, and increase the accuracy of the measurement data. When simulating measurements, we use the resistor and diodes to simulate the cell, verify that the functionality is what we need. In this theses, we also made two kinds of electrical stimulators, one is high pulse electric field stimulator, and the other is surge magnetic field stimulator. In high pulse electric field stimulator, we use the transformer and boost circuit to boost the input voltage for ours specify gain. In the output pins we let it floating, to make the air gap exist in output pins. When our stimulator starting, the electric field between output pins will continued to increase until the air gap breakdown voltage, and produce electric arc discharge, which makes continuous high pulse electric field around it. And the surge magnetic field stimulator we use the structure of transcranial magnetic stimulation (TMS), store electricity in the component. When stored to the specified voltage we trigger the switch, to produce a very high current, which can through a coil to generate surge magnetic field. The magnetic field normally use in human nerve stimulation, and also use in for our experiments. In the future, we hope the two stimulators will use in our cell experiments, and we can observe the causation for the changes of cell with electric field and magnetic field.