Synthesis of magnetic core–shell Fe3O4–Au nanoparticle for MRI/CT Hybrid Imaging Application

• Main Authors: Huang, Kuo-Chan, 黃國展
• Other Authors: Tsai, Chang-Shu
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/c53g6b

碩士 === 慈濟科技大學 === 放射醫學科學研究所 === 105 === Abstract To date, a wide variety of magnetic nanoparticles have been produced, differing in size and type of coating material,including dextran, citrate, starch,albumin, silicones and polyethyleneglycol. The diversified usage of magnetic nanoparticles were particularly in the biomedical applications including MRI contrast agent, hyperthermia, PET-MR contrast agent and drug delivery. Among the developed nanoparticles systems,superparamagnetic iron oxide nanoparticles have been extensively explored as a negative contrast agent for T2-weighted magnetic resonance imaging applications. In this study, we used the chemical co-precipitation method to prepare the superparamagnetic iron oxide nanoparticles, and coated with: good biocompatibility, can reduce the biological toxicity and make the nanoparticles more stable in human body and chemically stable effect. The selected of low molecular weights dextran as a magnetic nanoparticles interface active agent, and combined with the gold ion (of Au3+) onto the iron oxide nanoparticle’s surfaces via iterative hydroxylamine seeding, the combination of the two differentiation magnetic pole has potential for use in MRI/CT contrast agent applications. The MR and CT imaging data reveal that the formed Fe3O4@Au nanohybride have a relatively high r2 relaxivity (42.2s-1) and good X-ray attenuation property, which enables their uses as contrast agents for MR and CT imaging of water phantom. The Fe3O4@Au nanohybride developed via the co-precipitation approach may have promising potential for the dual-mode MR/CT.