Preparation of carboxylic and amine functionalities multilayer thin films by vacuum plasma system for biomedical applications

• Main Authors: Yi-Zeng Sun, 孫亦增
• Other Authors: Meng-Jiy Wang
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/92489905563313211143

碩士 === 國立臺灣科技大學 === 化學工程系 === 105 === Biomaterials such as contact lenses and biosensors are commonly suffered from biofouling problems, which lead to the product contamination, equipment dysfunction, and corrosion. This thesis was divided into two parts, at the first part, the scleral contact lenses were used as analytical material. The chemical composition, surface roughness, and surface morphology of contact lenses were characterized by XPS, AFM, and SEM, respectively. For the second part, zwitterionic polymers were synthesized by vacuum plasma polymerization. The feasibility to deposit positively charged allylamine (AAm) and negatively charged acrylic acid (AAc) monomers on different substrates by plasma-assisted polymerization technique was demonstrated for bio-related applications. For the first part of the thesis, the result from the XPS shows that the characteristic peaks of Si2p, which belong to contact lenses, disappeared after wearing for six months. And the characteristic peaks of N1s, which belong to protein, can be observed after wearing. The reason is due to the contact lenses surface was covered by the contaminants of proteins, lipids, organic and inorganic substances. For the second part of the thesis, the feasibility to deposit positively charged AAm and negatively charged AAc monomers on different substrates by plasma-assisted polymerization technique was demonstrated for bio-related applications. The results of protein adsorption indicated that the sample pp(AAm10/AAc10)8 shows the lowest amount of protein attached onto the surface, which is 1.5 μg/cm2 by using BSA (bovine serum albumin). On the other hand, the pp(AAm10/AAc10)4 shows the lowest amount of protein attached onto the surface, which is 1.2 μg/cm2 by using lysozyme. The results show that zwitterionic polymer thin film pp(AAm/AAc) possessing good antifouling property.