| Summary: | 碩士 === 國立臺灣大學 === 職業醫學與工業衛生研究所 === 105 === Background
Increasing numbers of observational studies suggest that shift work is associated with prostate cancer. However, the results remain controversial. We performed meta-analyses both of studies directly assessing shift work and those assessing shift work-related occupations, to clarify the suggested associations.
Methods
Relevant studies were identified by searching three databases to July 2016; the reference lists of the retrieved articles were also reviewed. We included observational studies that reported risk estimates with 95% confidence intervals (CIs) for the associations between shift work and the risk of prostate cancer. Random-effects models were used to calculate pooled risk estimates.
Results
A total of 26 studies with 2,785,457 participants involving 15,655 prostate cancer cases were included. A significantly increased risk of prostate cancer was evident in studies directly assessing shift work exposure (OR = 1.22, 95% CI 1.08–1.36) and those assessing shift work-related employment (OR = 1.17, 95% CI 1.10–1.24); however, substantial heterogeneities were apparent. The associations remained significant upon most subgroup and sensitivity analyses. Non-linear trend estimation revealed no significant dose-response relationship between cumulative exposure year of shift work and prostate cancer risk. The total number of prostate cancer deaths attributable to shift work is approximately 4,906 per year in the United States and Europe.
Conclusion
Our meta-analysis showed that shift work may be associated with an increased risk of prostate cancer. Further studies assessing different domains of shift work are warranted to confirm our findings and to clarify the biological mechanisms involved.
|
|---|
