Study of Clinical Features and Potential Therapeutic Target of Thymic Tumors

• Main Authors: Ting-Yu Lu, 呂庭聿
• Other Authors: 李章銘
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/8cb7yk

碩士 === 國立臺灣大學 === 臨床醫學研究所 === 105 === Thymic epithelial tumors, including thymomas and thymic carcinomas, are rare epithelial tumors of the thymus. Adequate surgical resection is the main treatment of this tumor. However, there is no effective target therapy for thymic tumor according to previous research. Because of its rarity and low grade malignant, there are only few researches of thymus in Taiwan. In order to find out the clinical features of Taiwanese patients, and potential treatment targets, we are going to perform this study. A total of 155 patients from National Taiwan University Hospital and China Medical University Hospital are included. According to our analysis, WHO classification and Masaoka stage are still the potential predictors of survival. Residence of patients and type II DM maybe correlate with invasiveness of tumor. According to our molecular biological results, unique expression features of SOCS5, RON and HSP90 in thymic tumor tissue are detected by Western blot. Synchronous performance of EGFR and SOCS5 are found in 6 pairs of tissue. Interesting, overexpression of HSP90 in tumor part is found in 7 pairs of tissue, which has never been reported. These may be the potential therapeutic target of this disease in the future.