A Study of CMOS-BioMEMS Based Piezoresistive Microcantilever Sensor on the Detection of Gentamicin for Patients with Peritonitis

• Main Authors: Kuan-Wei Li, 李冠緯
• Other Authors: 張培仁
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/04865395495429052125

碩士 === 國立臺灣大學 === 應用力學研究所 === 105 === The study prove that piezoresistive microcantilever can accomplish the low cost, portable, minimization sample and quantitative analysis the small molecule drug which is made by CMOS MEMS process and integrate the technique of electric field at the same time. Accroding to the experiment ruslt, the quantitative analysis curve contain the effective treatment range of Gentamicin which is measured by piezoresistive microcantilever. So piezoresistive microcantilever have the great potential to implement the TDM for patient to monitor the concentration of Gentamicin in blood. In rescent year, there is the growing number of the need of the sensor which can portable and timely detection for lots of detection had been emphasized. The surroundings of medical treatment have being taken seriously. So the need of home care growing year by year. The growing number of the need of protable detection sensor is to fulfill the home care. Adverse drug reaction has received increasing attention recently. For some specific drugs with narrow therapeutic ranges, use of therapeutic drug monitoring (TDM) may reduce the adverse drug reactions for an individual to avoid drug toxicity. Gentamicin, managed in TDM, is a widely used antibiotic drug for patients with renal failure. This drug, composed of a mixture of related gentamicin components and fractions, is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. The piezoresistive microcantilever is made by TSMC CMOS MEMS 0.35 process which integrate the MEMS and BioMEMS technique and package by low cost. The piezoresistive microcantilever can detect the small molecule drug and promote the sensitivity by control the electric field to detect more lower concentration By comparing the change of the signals in no electric field of antibody immobilization and 60 volt electric field of antibody immobilization, the result showed that the average singal promote 1.8 times. The quantitative analysis after 60 volt electric field of antibody immobilization show that the different concentration of Gentamicin which contain 10 μg/mL、20 μg/mL、35 μg/mL、50 μg/mL、150 μg/mL、200 μg/mL got the signal indivudlly．5.030 mΩ、20.912 mΩ、40.854 mΩ、62.087 mΩ、125.796 mΩ、123.391 mΩ. according to the result of Gentamicin, it can obtain a quantitative analysis curve of TDM patient.