Characteristics of a New Photosensitizer (tetramino-zinc-phthalocyanine) and Its Cancer Cell Damage Effects

• Main Authors: Jian-He Yu 余建和, 余建和
• Other Authors: 楊志忠
• Format: Others
• Language: en_US
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/j2q59n

碩士 === 國立臺灣大學 === 光電工程學研究所 === 105 === A new type of Pc-series photosensitizer, tetramino-zinc-phthalocyanine (ZnPcN), which can link with alpha-Thio-omega-carboxy poly(ethylene glycol) (HS-PEG-COOH) through covalent bonding, such that its linkage with an Au nanoparticle (NP) becomes stronger for reducing the escape rate is synthesized. After demonstrating its fundamental photosensitizer characteristics, its escape behavior is compared with that of the commonly used PcS-series photosensitizer, tetrasulfonate-aluminum-phthalocyanine (AlPcS), through the measurements of the decreasing trends of absorption and cell damage efficiency with increasing waiting time. It is found that the escape of ZnPcN is indeed slower than that of AlPcS. For ZnPcN, the cell damage efficiency decreases most significantly in the first 10 min of waiting and saturates 30 min after incubation. However, for AlPcS, the cell damage efficiency keeps decreasing with waiting time up to 4 hours after incubation. The stronger chemical bonding between ZnPcN and HS-PEG-COOH leads to less ZnPcN escape and hence a longer waiting time of high cell damage capability, when compared with the electro-static bonding between AlPcS and HS-PEG-NH2.