| Summary: | 碩士 === 國立臺灣海洋大學 === 食品科學系 === 105 === Hyperuricemia is a disease caused by high uric acid in the blood. It has been
considered as an important factor for gout and may be linked to hypotension,
hyperlipidemia, diabetes, metabolic syndrome and cardiovascular diseases. The aims
of this study are to evaluate of the hypouricemic effects of submerged culture of
Ganoderma lucidum in hyperuricemic rats. The dried weight yields for the mycelium
and extracellular polysaccharides in the submerged culture of G. lucidum were 3.84 ±
0.37 g/L and 0.21 ± 0.04 g/L, respectively. The contents of phenolics in the
lyophilized powder of submerged culture of G. lucidum (GS)、mycelium (GM) and
extracellular polysaccharides (GP) were 24.57、34.33、20.52 mg GAE/g dry weight,
respectively. The contents of flavonoids in the lyophilized powder of mycelium was
0.32 mg QE/g dry weight. Sprague-Dawley rats were induced to hyperuricemic rats
by intraperitoneal injection potassium oxonate (PO) (250 mg/kg b.w.), and randomly
divided into seven groups of 8 animals: (1) Normal control, NC (2) Hyperuuricemic
control, HC (3) HC + allopurinol (10mg/kg b.w.), HA (4) HC + GM (200 mg/kg b.w.),
HM2 (5) HC + GM (400 mg/kg b.w.), HM4 (6) HC + GP (200 mg/kg b.w.), HP2 (7)
HC + GP (400 mg/kg b.w.), HP4. The average daily body weights of all induced
hyperuricemic rats were significantly higher than that of N group. The serum uric acid
levels for HC group was significantly higher than the N group (p < 0.001). The serum
uric acid levels for HA and HM2 groups was significantly decrease (p < 0.001). The
liver xanthine oxidase activity for HM2 and HM4 group were significantly lower than
that of HC group (p < 0.001). The plasma BUN levels for HM4、HP4 and HP4 groups
were significantly decrease. The ALT levels for HP2 and HP4 groups were
significantly lower than that of N group. These results demonstrated that feeding the
hyperuricemic rats with G. lucidum mycelium at the dosage of 200 mg/kg b.w. could
significantly decrease the serum uric acid level.
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