Highly Enantioselective Synthesis of Cyclopentane from Newly Developed Coumarin Derivatives by Organocatalytic Asymmetric (3+2) Cyclization

• Main Authors: Chen, Kai-Han, 陳楷涵
• Other Authors: Lin, Wen-Wei
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/kefd2q

碩士 === 國立臺灣師範大學 === 化學系 === 105 === Coumarin derivatives have the large biological activity, and in nature are also important natural product, therefore, how to make the addition on coumarin derivatives becomes a very important issue. In the past, we mostly construct five heteroatomed ring on the coumarin in asymmetric-organocatalyzed reaction. Nowadays, we use the newly developed coumarin derivatives as the substrates, and develope the great strategy to establish the five-carbon ring on the coumarin derivatives, and use the intermediates to figure out this reaction mechanism. In the second part, the synthesis of complex compounds in organic reactions usually requires the construction of the steps via the multi-step reaction step. However, due to the fact that the multi-step reaction is liable to the waste of resources, so research has become an important subject through the domimo reaction. This part focusing on the development of serial reaction initiation ideas and test results.