| Summary: | 碩士 === 國立屏東科技大學 === 食品科學系所 === 105 === Naringenin, a type of flavonoid, is considered to have a bioactive effect on human health. Naringenin has been used as a traditional anti-inflammatory agent for centuries; however, the molecular mechanism for anti-inflammation in intestinal remains unknown so far. The present study investigated a molecular basis for the protective effect of naringenin in dextran sulfate sodium-induced murine colitis models of inflammatory bowel disease (IBD). The doses of naringenin per day per mice were 10, 50, and 100 mg/kg bw respectively. Colitis was induced by administration of 3% dextran sulfate sodium (DSS) in drinking water for 7 days. DSS administration caused severe colon damage and inflammation, as showed by body weight loss, increased clinical sores, and the colon shortening. Experimental results show that feeding naringenin can prevent the sodium dextran sulfate (DSS) induced inflammation through the inactivation of macrophage.
|
|---|
