Association between genetic polymorphisms of bone mineral density and osteopenia among older adults in Taiwan

• Main Authors: TSAI, DUNG-JANG, 蔡東樟
• Other Authors: SU, SUI-LUNG
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/8kygas

碩士 === 國防醫學院 === 公共衛生學研究所 === 105 === Background: Osteoporosis is one of the chronic diseases of the elderly, which is commonly found in the elderly population, and the prevalence rate of osteoporosis increases with age.The cause of osteoporosis is complex, and bone density is generally lost with age, Some factors will cause loss of bone such as lack of exercise, smoking, drinking, lack of calcium diet, lack of sunbathing.Especially genetic factors may play an important role, and many studies have previously found that bone density is associated with genes. Objective: The objective of this study was to investigate the association between genetic polymorphisms of Bone mineral density and osteopenia among older adults in Taiwan. Material and methods: In this study, We performed a case-control study and included 418 participants who received health examination in Health Management Center of Tri-Service General Hospital from March, 2015 to August, 2016. For each participant, demographic data were obtained by structured questionnaire, and BMD was measured by dual-energy x-ray absorptiometry (DXA). Results: After adjusted age, sex and BMI, the frequencies of rs4986938 (ESR2) CT genotype were decreased risk of osteopenia than CC genotype (OR=0.43, p=0.004).T allele were decreased risk of osteopenia than C allele (OR=0.49, p=0.006). CT+TT genotype were decreased risk of osteopenia than CC genotype (OR=0.43, p=0.004).The frequencies of rs3801387 (WNT16) GA genotype were decreased risk of osteopenia than AA genotype (OR=0.51, p=0.013).G allele were decreased risk of osteopenia than A allele (OR=0.59, p=0.023). GA+GG genotype were decreased risk of osteopenia than AA genotype (OR=0.53, p=0.013). Conclusion: In the elderly population, rs4986938 (ESR2) and rs3801387 (WNT16) were associated with osteopenia.