The Association of Melatonin Secretion with the risk of Metabolic Syndrome

• Main Authors: HO, CHIA-JUNG, 何佳容
• Other Authors: CHOU, YU-CHING
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/546y99

碩士 === 國防醫學院 === 公共衛生學研究所 === 105 === Background: The metabolic syndrome (MetS) is comprised of several metabolic abnormalities. The incidence of metabolic syndrome among affluent countries increased steadily. Recent studies indicate that circadian system disarrangement and sleep disorders contribute to the development of metabolic syndrome. Objectives: The study was aimed to (i) examine the relationship between sleep quality and MetS, (ii) assess the association between serum melatonin levels and the risk of MetS, (iii) evaluate the joint effect of sleep quality and serum melation on the risk of MetS. Methods: We performed a case-control study. Case and control subjects recruited from the Show-Chwan Memorial Hospital in the Changhua area. Subjects who met at least 3 criteria of MetS as defined by Health Promotion Administration, Ministry of Health and Welfare were defined as cases with MetS. Control subjects matched to each case by age (±5 years) and sex were selected from those who attended the health check-up at the Show-Chwan Memorial Hospital. Global sleep quality was measured using the validated Chinese version of the Pittsburgh Sleep Quality Index. All subjects underwent 12-hour overnight fasting and blood sampling for serum melatonin and basic biochemical analysis. Results: Poor sleep quality had a multivariable odds ratio of 1.15 (95% CI=0.77-1.73) for developing metabolic syndrome. In addition, low melatonin secretion had a multivariable odds ratio of 1.12 (95% CI=0.72-1.74) for developing metabolic syndrome. Furthermore, when compared with subjects with well sleep quality and high melatonin secretion, those with poor sleep quality and low melatonin secretion had a multivariable odds ratio of 1.14 (95% CI=0.60-2.15) for developing metabolic syndrome. Conclusions: Poor sleep quality and low melatonin secretion were associated with a higher risk of developing metabolic syndrome. Further studies are needed to explore the mechanisms of poor sleep quality in the risk of metabolic syndrome. Keywords: Case-control study, metabolic syndrome, serum melatonin, sleep quality.