Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells

碩士 === 國立東華大學 === 生命科學系 === 105 === Multiple Myeloma (MM) is a disease caused by abnormal plasma cells. Interleukin-6 (IL-6) is an essential growth factor for MM cells and it can activate PI3K/AKT pathway, JAK/STAT pathway, and RAS/MAPK signaling pathway. These pathways affect anti-apoptosis and pro...

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Main Authors:	Chen-An Hsu, 徐晨安
Other Authors:	Jung-Hsin Hsu
Format:	Others
Published:	2017
Online Access:	http://ndltd.ncl.edu.tw/handle/bq8u6d

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spelling	ndltd-TW-105NDHU51080032018-05-15T04:31:47Z http://ndltd.ncl.edu.tw/handle/bq8u6d Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells 人類角鯊烯合成酶胜肽抑制劑對多發性骨髓瘤細胞生長的影響 Chen-An Hsu 徐晨安碩士國立東華大學生命科學系 105 Multiple Myeloma (MM) is a disease caused by abnormal plasma cells. Interleukin-6 (IL-6) is an essential growth factor for MM cells and it can activate PI3K/AKT pathway, JAK/STAT pathway, and RAS/MAPK signaling pathway. These pathways affect anti-apoptosis and proliferation in MM cells. Among them, AKT plays an important role in PI3K/AKT pathway. Cholesterol plays important roles in living cells. Human Squalene Synthase, the rate-limiting enzyme locates at the downstream of cholesterol synthesis pathway. Preliminary data show that some peptides can inhibit the growth of myeloma cells. Whether this is an induced-apoptosis phenomenon by these peptides waits for further investigations. Jung-Hsin Hsu 許榮欣 2017 學位論文 ; thesis 51
collection	NDLTD
format	Others
sources	NDLTD
description	碩士 === 國立東華大學 === 生命科學系 === 105 === Multiple Myeloma (MM) is a disease caused by abnormal plasma cells. Interleukin-6 (IL-6) is an essential growth factor for MM cells and it can activate PI3K/AKT pathway, JAK/STAT pathway, and RAS/MAPK signaling pathway. These pathways affect anti-apoptosis and proliferation in MM cells. Among them, AKT plays an important role in PI3K/AKT pathway. Cholesterol plays important roles in living cells. Human Squalene Synthase, the rate-limiting enzyme locates at the downstream of cholesterol synthesis pathway. Preliminary data show that some peptides can inhibit the growth of myeloma cells. Whether this is an induced-apoptosis phenomenon by these peptides waits for further investigations.
author2	Jung-Hsin Hsu
author_facet	Jung-Hsin Hsu Chen-An Hsu 徐晨安
author	Chen-An Hsu 徐晨安
spellingShingle	Chen-An Hsu 徐晨安 Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
author_sort	Chen-An Hsu
title	Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
title_short	Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
title_full	Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
title_fullStr	Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
title_full_unstemmed	Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
title_sort	using peptide inhibitors of human squalene synthase to inhibit the growth of multiple myeloma cells
publishDate	2017
url	http://ndltd.ncl.edu.tw/handle/bq8u6d
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Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells

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