Using Peptide Inhibitors of Human Squalene Synthase to Inhibit the Growth of Multiple Myeloma Cells
碩士 === 國立東華大學 === 生命科學系 === 105 === Multiple Myeloma (MM) is a disease caused by abnormal plasma cells. Interleukin-6 (IL-6) is an essential growth factor for MM cells and it can activate PI3K/AKT pathway, JAK/STAT pathway, and RAS/MAPK signaling pathway. These pathways affect anti-apoptosis and pro...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Published: |
2017
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/bq8u6d |
| Summary: | 碩士 === 國立東華大學 === 生命科學系 === 105 === Multiple Myeloma (MM) is a disease caused by abnormal plasma cells.
Interleukin-6 (IL-6) is an essential growth factor for MM cells and it can
activate PI3K/AKT pathway, JAK/STAT pathway, and RAS/MAPK signaling
pathway. These pathways affect anti-apoptosis and proliferation in MM cells.
Among them, AKT plays an important role in PI3K/AKT pathway. Cholesterol
plays important roles in living cells. Human Squalene Synthase, the rate-limiting
enzyme locates at the downstream of cholesterol synthesis pathway. Preliminary
data show that some peptides can inhibit the growth of myeloma cells. Whether
this is an induced-apoptosis phenomenon by these peptides waits for further
investigations.
|
|---|