| Summary: | 碩士 === 國立中央大學 === 系統生物與生物資訊研究所 === 105 === Association between Sjögren's syndrome (SjS) and liver disease was indicated in 1954. Up to now, many studies have indicated that SjS and viral-hepatitis are correlated. However, association between SjS and non-viral hepatitis was rarely studied. In this study, we used clinical data from Cathay General Hospital and Landseed Hospital and supplemented by NHIRD to analyse the association between SjS and non-viral hepatitis. We found that SjS patients was usually diagnosed with hepatitis (ICD9-Codes: 573.3) and chronic hepatitis (ICD9-Codes: 571.40) (P-value: 6.29E-14 to 2.82E-123). To understand what factors elevated the prevalence of hepatitis in patients with SjS, we supposed the following factors of rising diagnosis: temperature, humidity, gender, age, types of SjS and medicines. The result shows that temperature, humidity, gender and types of SjS do not impact on prevalence of hepatitis in adult patients with SjS (P-value >0.05). However, 50 to 70 year-olds’ patients have higher prevalence of hepatitis. Most of medicines elevate the risk of hepatitis, and patients take more medicines, the prevalence of hepatitis are also higher in adult SjS patients.
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