| Summary: | 碩士 === 國立交通大學 === 生醫工程研究所 === 105 === We proposed a high-frequency ventricular defibrillation system output power stage design and investigated the effects of high-frequency defibrillation on the isolated heart. The high-frequency defibrillation system delivers traditional biphasic, 250Hz exponential decaying, 500Hz exponential decaying, and 1000Hz exponential decaying waveform in: pacing interval S1 fixed to 200ms, S2 interval varying from 50ms to 150ms with 25ms interval condition. Action potential was recorded during and after the defibrillation shock and pacing by optical mapping technology. The highest ventricular fibrillation (VF) induced rate (VF vulnerability) located at S2 interval of 100ms, which increases the VF vulnerability from 4% to 42%. The increasing frequency also shows 500% increasing VF vulnerability from traditional biphasic defibrillation shock.
The results suggest that high-frequency defibrillation waveforms could have higher defibrillation efficacy than traditional biphasic waveform.
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