(I) Synthesis of benzimidazole linked indoline derivative by acid catalyst(II) One-pot synthesis of derivative of ellipticine which has the activity against Mycobacterium tuberculosis

• Main Authors: Chiu, Feng-Yu, 邱夆昱
• Other Authors: Sun, Chung-Min
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/3snnw5

碩士 === 國立交通大學 === 應用化學系碩博士班 === 105 === This thesis has two parts: The first part is about synthesis of benzimidazole linked indoline derivatives from C-2-linked-o-aminobenzyl benzimidazole by acid catalyst. This method can apply to various funtional groups. There is no published paper refer to benzimidazole linked indoline derivatives, so we hope these heterobicyclic molecules can show more bioactivity and also hope this thesis can open a new page for research of drugs. The second part is about One-pot synthesis of derivative of ellipticine which has the activity against Mycobacterium tuberculosis. We hope we can improve its activity of anti-TB by changing different funtional groups to study the structure–activity relationship.