Research and application for binocular synchronous pupillometry

• Main Authors: Tsai, Yi-Chun, 蔡宜君
• Other Authors: Ou-Yang, Mang
• Format: Others
• Language: en_US
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/26944283621238038948

碩士 === 國立交通大學 === 電控工程研究所 === 105 === Eye provides the ability of vision. In addition, its change and situation can reveal physiological state for human. The special phenomenon is pupillary light reflex. The purpose of this phenomenon is to adjust light which enters pupil and prevent retina from being impaired. It is controlled by autonomic nervous system. Autonomic neuropathy is usually unobvious and difficult to find. Because of quantification and variability, it does not distinguish the situation of neurotransmission by data in the current instruments and measurement methods. Therefore, this research studies the neurotransmission and autonomic neuropathy by pupillary light reflex. This study designs a non-invasive, portable, and binocular pupillometer. The light sources contain two intensity and four wavelength to measure pupil size, latency, and velocity. This study has two main directions. First, it studies binocular neurotransmission for healthy people. Second, pupil response is compared between normal and patients, such as diabetics and Gaucher disease. The experiment of neurotransmission proves the difference of latency through dissimilar resolution preliminarily for normal. The latency of stimulated eye is shorter than unstimulated eye. The experimental results for diabetics are as follows: The resting pupil diameter of diabetics is smaller than normal (p=0.03). Diabetics have longer time to constriction under white light and intensity of 0.12cd (p=0.016). Duration between the minimum pupil size restoring to the 50% pupil size for diabetics is longer than normal under different luminous intensity and wavelength (p=0.027). The maximum pupil constriction velocity is faster than healthy people under red and blue (p=0.043). Maximum pupil restoration velocity is slower than normal under white and red light (p=0.045). The experimental results for Gaucher disease are as follows: Minimum pupil diameter and restoring to 50% pupil diameter are larger than healthy people under red light (p=0.004).