Study on the Synthesis of Oxazolo[2,3-a]tetrahydroisoquinolines via Tandem Reaction
碩士 === 國立暨南國際大學 === 應用化學系 === 105 === 1,3-Oxazolidine frameworks were found in natural products and pharmaceutical compounds. In this research, addition of -hydroxy-,-unsaturated ketones 30 with 3,4-dihydroisoquinolines 49 provided oxazolo[2,3-a]tetrahydroisoquinoline 50 derivatives via tandem re...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2017
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| Online Access: | http://ndltd.ncl.edu.tw/handle/929d5v |
| Summary: | 碩士 === 國立暨南國際大學 === 應用化學系 === 105 === 1,3-Oxazolidine frameworks were found in natural products and pharmaceutical
compounds. In this research, addition of -hydroxy-,-unsaturated ketones 30 with 3,4-dihydroisoquinolines 49 provided oxazolo[2,3-a]tetrahydroisoquinoline 50 derivatives via tandem reaction involving nucleophilic addition and aza-Michael addition. The reaction proceeded under mild condition without catalyst and finished in 15 minutes, giving the various products with good to excellent yields (85-98%) and high diastereoselectivity (up to 25:1 dr). The relative stereo-structure of the products were confirmed by NMR technique and X-ray crystallography. This synthetic strategy corresponded with “green chemistry” and atomic economy.
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