| Summary: | 碩士 === 國立成功大學 === 環境工程學系 === 105 === There are various kinds of endocrine disrupting chemicals (EDCs) present in the effluent of wastewater treatment plants (WWTPs), such as chemicals showing disrupting activities for aryl hydrocarbon receptor (AhR), androgen receptor (AR), or mineralocorticoid receptor (MR). These EDCs may further react with chlorine to form chlorinated derivatives in disinfection process of WWTPs. In this study, samples from different treatment stages of WWTPs were collected and analyzed by recombinant yeast bioassays and LC-MS/MS to investigate the endocrine disrupting activities and concentrations of target EDCs and their chlorinated derivatives. Our results showed that AhR agonist activities, anti-androgenic activities, and anti-mineralocorticoid activities were detected frequently in the dissolved phase of WWTP influents and effluents. The chlorinated derivatives of selected EDCs still showed AhR agonist activities, AR antagonist activities, and MR antagonist activities in the bioassays, which were even stronger than their parent compounds. LC-MS/MS results showed that some EDCs, such as methylparaben, nonylphenol, and triclosan were often detected at ng/L to μg/L levels. In addition, chlorinated derivatives of methylparaben and bisphenol A were also often detected in WWTP samples. More attention should be paid to the formation of chlorinated EDCs and their potential risk to aquatic organisms.
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