| Summary: | 碩士 === 國立成功大學 === 機械工程學系 === 105 === Temporal lobe epilepsy is the common form of partial epilepsy. Although antiepileptic drugs have been found, there are still 30% of patients who cannot benefit from these treatments. Only a minority of patients are suitable for resection of lesion sites, so new method needs to be developed to inhibit seizure. The purpose of this study is to develop a control system to suppress chronic seizure by using photic stimulation. To simulate human seizure in the animal experiment, the Thy1-ChR2-YPF transgenic mice were injected with lithium and pilocarpine to induce acute and chronic seizure. Then, two electrodes and an optical fiber were implanted into the hippocampus of the mice. Depth-EEG measured from mice is used to design the detection and control system. The sample entropy calculated from contralateral depth-EEG was utilized to recognize epileptics state and to adjust the intensity of photic stimulation by using a piecewise linear proportional law in the control system. The results from 10 subjects showed seizure recognition rate can rise up to 95% in the acute stage and 85 to 90% in the chronic stage. The photic stimulation can swiftly and effectively inhibit seizure for both acute and chronic stages, and the highest suppression rate achieved was 98.3% in the chronic stage. In conclusion, sample entropy method and photic stimulation technology may provide a new direction of development on treating temporal lobe epilepsy in the future.
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