Host-mimetic concept applied to design biomaterials: zirconia-based coatings upon indwelling needle and porous titanium scaffold

• Main Authors: HanLee, 李含
• Other Authors: Bernard HaoChih Liu
• Format: Others
• Language: en_US
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/z4r4v4

博士 === 國立成功大學 === 材料科學及工程學系 === 105 === Living organisms have evolved well-adapted structures through natural selection that inspires human to look for answers to our lives’ problems. The host-mimetic is the imitation of the models and systems of nature, which can be influential to the complex of human problem solving. This dissertation presents the study of functionally designed host-mimetic applications; including zirconia (ZrO2) based indwelling needle and porous titanium (Ti) scaffold. For the former, 316L stainless steel (SS) plate was coated with ZrO2 (ZrO2/316L) using the sol-gel dip coating technique. The results indicate that the in vitro and in vivo responses are most likely induced by the bio-inertness of the ZrO2 coating, which significantly reduces the impact of the wound healing process and is thus suitable for a tissue-invasive surface. The ZrO2/316L_500 needle exhibits high potential to be applied to scalpels and indwelling needles. In order to increase biocompatibility and mechanical properties of the as-prepared ZrO2/316L, a modified sol-gel process that uses PEG as the binding agent was applied. Examination of the cell morphology, growth, and viability on the surfaces of ZAN_400_5 and ZANP_400_5 indicates no cytotoxic effect. For the later, porous Ti scaffolds for bone spacer was developed based upon powder metallurgy. The load-bearing capacity, porosity, pore size, and biocompatibility of Ti_1000_50 make it become promising for the lumbar disc of the spine or a part of trabecular bone. The quality of porous Ti could be further improved by ZrO2 coating, for instance, the cell affinity. The combination of porous Ti characteristics and biocompatible ZrO2 coating is expected to have high potential applications not only for scaffolds but also for other biomimetic applications.