Enhancement of Drug-Loading Capability for the Polymeric Micelles via Co-Encapsulation with Triglyceride

• Main Authors: Ling-TaoChi, 紀凌濤
• Other Authors: Wen-Chung Wu
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/54k6yz

碩士 === 國立成功大學 === 化學工程學系 === 105 === In this study, we developed a novel, dual-sensitive drug carrier based on polymeric micelles co-assembled from amphiphilic block copolymers, [PCL-b-P(TEGMA-co-AHA)] (PTAHA), with tricaprin, a kind of medium-chain triglyceride (MCT). PTEGMA possessed thermo-sensitive and AHA performed pH-sensitive in aqueous solution. The micelles, PTAHA/MCT, were designed to improve capability of Doxorubicin (DOX) loading and compared to blank micelles, PTAHA, as control. Among micelles, PCL and MCT formed a mixed hydrophobic domain known as micellar emulsion to encapsulate DOX. In physical properties, PTAHA/MCT micelles had bigger size and higher LCST at pH 5.33 buffer. In drug loading experiments, PTAHA/40% MCT had the highest loading content (LC) and entrapment efficiency (EE) to DOX. Moreover, PTAHA/MCT/DOX micelles performed superior stabilities at 37oC in aqueous solution. DOX in PTAHA/MCT micelles could release fast at acidic aqueous media within one hour while maintained in core at neutral. This was supposed that PTAHA/MCT micelles were adequate to be a drug carrier to encapsulate DOX.