| Summary: | 碩士 === 國立中興大學 === 生醫工程研究所 === 105 === We designed and synthesized a series of 2, 5-bis (1-alkyl-4-vinylpyridinium) thiophene derivatives, TOP. The water-soluble aggregation-induced emission (AIE) these fluorogen can generate particular reactive oxygen species (ROS) to undergo photodynamic therapy once irradiation. Prior to irradiation, this compound can specifically localize in mitochondria, while irradiation treatment induced an intra-cellular relocalization into the nucleus and nucleoli and cause photo-toxicity to cancer cells but not normal cells. We conclude that these compounds are potential theranostic molecules because it exhibits selective photo-toxicity and cell death biomarker dual functions. On the other hand, the AIE fluorogen C4TOP can be conveniently encapsulated by silanization (Stöber) method to construct the FON@OH. Systematic investigations verify that the resulting FON@OH could display extremely conservative, solvent-independent and photo-stability optical properties in aqueous media as well as in most organic solvents. This novel fluorescent nanoparticle is very suitable to be a biomarker use once after surface modified.
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