A Study on Anti-Sticking of Protein after Atmospheric Pen-Like Plasma Surface Treatment of Silicone Graft Polymerization

• Main Authors: Chen, Yu-Ching, 陳幼晴
• Other Authors: Weng, Wen-Pin
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/48198848771924653710

碩士 === 龍華科技大學 === 化工與材料工程系碩士班 === 105 === Silicone is a chemically stable, resistant to high temperature and non-toxic materials. It always get much attention when it comes to the storage and transport of blood, drugs and other implantable medical devices. However the surface properties of polymer materials and human structure are incompatible, its implantation to human body always lead to rejection, tissue infection, inflammation, and necrosis. In this study, we tried to modify the silicone surface and improve its hydrophilic properties and adhesion resistance of protein to get optimum process parameters. Two kinds of material, sulfobetaine methacrylate (SBMA) and polyethylene glycol (PEG), were used to proceed two kinds of graft polymerization: thermal polymerization and plasma polymerization. Improvements on hydrophilicity, resistance to protein adhesion on the surface of silicone and the medical applicability were discussed. Experimental result show that the hydrophilic angle of silicone can be reduced to as low as 7.7 ° after its surface modification under the conditions: 90 W of plasma power; 15 liters per minute of gas flow rate; and 15 seconds of surface treatment. Thermal polymerization is far better than plasma polymerization. The amount of protein sticking to the modified silicone can be largely reduced when we control the concentration of SBMA and PEG at 0.1M before graft polymerization.