| Summary: | 碩士 === 高雄醫學大學 === 醫學研究所碩士班 === 105 === Objective:
To evaluated the association between gout and the risk of benign prostatic hyperplasia among men by applying data Taiwan’s National Health Insurance Research Database (NHIRD)
Methods:
Population-based representative insurance (outpatient and inpatient) claims data of 29269 patients with gout and 29269 controls without gout (1:1, case: control ratio) between 1997 and 2010 in Taiwan were identified. The relation between gout and benign prostatic hyperplasia was evaluated using the Cox proportional hazards model. Moreover, association of early onset gout with benign prostatic hyperplasia and association of gout phenotypes with benign prostatic hyperplasia were estimated.
Results:
In total, 4418 (15.09%) patients with gout and 3847 (13.14%) controls developed benign prostatic hyperplasia in the follow-up period. Multivariate analyses revealed a significant association between gout and benign prostatic hyperplasia. Compared with the control group, the adjusted hazard ratios[HR] (95% confidence intervals [CIs]) for benign prostatic hyperplasia were 1.30 (1.24-1.36). The gout to benign prostatic hyperplasia association was modified by age (P interaction<0.0001), and it was significant in adults with age 20-40 years (adjusted HR=2.74, P<0.0001) and 40-60 years (adjusted HR=1.39, P<0.0001), but not in age>60 years (adjusted HR=1.07, P=0.063). Moreover, compared with gouty tophi, a significantly higher risk of benign prostatic hyperplasia was noted in gouty nephropathy (adjusted HR=1.24, 95% CI=1.08-1.44)
Conclusion:
Our results suggest that male gout is positively related to benign prostatic hyperplasia, particularly in gout patients younger than 40 years and gouty nephropathy.
Keywords:
Retrospective cohort study; Gout; Age; Benign prostatic hyperplasia
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