Characterization and Antibacterial Efficacies of Silver-Containing Polyvinyl Alcohol/Chitosan Composite Hydrogels

• Main Authors: WEI HO-CHIH, 魏合志
• Other Authors: KO TSE-HAO
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/48721867341960742710

碩士 === 逢甲大學 === 材料科學與工程學系 === 105 === Poly(vinyl alcohol) (PVA) which has good physical properties and biocompatibility but no antibacterial activities is being utilized as wound dressings. Chitosan (CS) is a widely used material for its antibacterial activities and good biocompatibility. This study discussed a hydrogel produced by mixing poly(vinyl alcohol) and chitosan and using glutaraldehyde (GA) as a chemical cross-linking agent. Silver particles were then added into the hydrogel by the redox reaction of nitrate (AgNO3) solution. These silver particles which exhibited antibacterial activities were attached to the internal three-dimensional network structure of the hydrogel. Both the physical properties and antibacterial activities of the hydrogel were exanimated. The experimental results showed that the PVA was cross-linked with CS, and the addition of CS had increased the swelling rate of the hydrogel. The specimen 2P3CG exhibited the best swelling rate of 376%. It was known that little CS could enhance the tensile strength of a hydrogel. This was confirmed in the tensile test that the tensile strength of specimen 6P0.5CG was increased by 200% compared to specimen 6P. Scanning electron microscope (SEM) observed the hydrogel consisted of a dense and complete three-dimensional network structure. The antibacterial activities of adding silver particles to the hydrogel were confirmed by antibacterial tests.