Investigation of Hydrogel Polymerization by Brownian Motion of Gold Nanoparticles

• Main Authors: Wei-Hsu Chen, 陳威旭
• Other Authors: Cheng-An Lin
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/92435038417863960754

碩士 === 中原大學 === 奈米科技碩士學位學程 === 105 === Hydrogel is a kind of soluble polymer with network crosslinking structures which is applied to biomedical applications by absorbing massive water molecules. Photoinitiator is added and UV energy(excitation light) further polymerizes polymer into hydrogel. But , duration of irradiating influences efficiency of absorbing water and generates byproduct causing pollution. Controlling duration of hydrogel polymerization is very important. To date, there is no related researches observing in real-time and analyzing polymerization process of hydrogel. Gold nanoparticles as usual biosensors are abundant in scattering and brownian motion properties in liquid. Scattering and Brownian motion of gold particles can be observed by the dark-field microscope and be biosensors of various liquid environment by tracking motion locus and analyzing speed variation. Analyzing speed variation of Brownian motion before and after polymerization of hydrogel can be a reference of polymerization of duration. In this study, gold nanoparticles are regarded as an optical sensor, adding various percentage of polymer acquires the most proper ratio. And adding photoinitiator of various concentration with UV energy polymerizes polymer to hydrogel. Adjusting spectra, energy, particle size analyzes response of polymerization and the dark-field microscope is utilized to observe and track speed variation of particles due to Brownian motion in real-time. Recording terminal of Brownian motion represents the duration of polymerization process. Finally, frequency of UV light is adjusted to achieve to acquire more specific polymerization process. And detailed database of polymerization duration of hydrogel is built up to provide a platform controlling the process so that hydrogel in biomedical applications is further enhanced.